Effects of ivermectin and midecamycin on ryanodine receptors and the Ca(2+)-ATPase in sarcoplasmic reticulum of rabbit and rat skeletal muscle

1. Ryanodine receptor (RyR) Ca(2+) channels in the sarcoplasmic reticulum (SR) of skeletal muscle are regulated by the 12 kDa FK506- (or rapamycin-) binding protein (FKBP12). Rapamycin can also activate RyR channels with FKBP12 removed, suggesting that compounds with macrocyclic lactone ring structu...

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Bibliografiske detaljer
Main Authors: Ahern, Gerard P, Junankar, Pauline R, Pace, Suzy M, Curtis, Suzanne, Mould, Jorgen A, Dulhunty, Angela F
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 1999
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2269079/
https://ncbi.nlm.nih.gov/pubmed/9852316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.1999.313ae.x
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