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Combined Inhaled Diesel Exhaust Particles and Allergen Exposure Alter Methylation of T Helper Genes and IgE Production In Vivo

Changes in methylation of CpG sites at the interleukin (IL)-4 and interferon (IFN)-γ promoters are associated with T helper (Th) 2 polarization in vitro. No previous studies have examined whether air pollution or allergen exposure alters methylation of these two genes in vivo. We hypothesized that d...

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Hlavní autoři: Liu, Jinming, Ballaney, Manisha, Al-alem, Umaima, Quan, Chunli, Jin, Ximei, Perera, Frederica, Chen, Lung-Chi, Miller, Rachel L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268643/
https://ncbi.nlm.nih.gov/pubmed/18042818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfm290
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