A virocidal amphipathic α-helical peptide that inhibits hepatitis C virus infection in vitro

An amphipathic α-helical peptide (C5A) derived from the membrane anchor domain of the hepatitis C virus (HCV) NS5A protein is virocidal for HCV at submicromolar concentrations in vitro. C5A prevents de novo HCV infection and suppresses ongoing infection by inactivating both extra- and intracellular...

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Detalhes bibliográficos
Main Authors: Cheng, Guofeng, Montero, Ana, Gastaminza, Pablo, Whitten-Bauer, Christina, Wieland, Stefan F., Isogawa, Masanori, Fredericksen, Brenda, Selvarajah, Suganya, Gallay, Philippe A., Ghadiri, M. Reza, Chisari, Francis V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268589/
https://ncbi.nlm.nih.gov/pubmed/18287023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712380105
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