Quantitative biochemical rationale for differences in transmissibility of 1918 pandemic influenza A viruses

The human adaptation of influenza A viruses is critically governed by the binding specificity of the viral surface hemagglutinin (HA) to long (chain length) α2-6 sialylated glycan (α2-6) receptors on the human upper respiratory tissues. A recent study demonstrated that whereas the 1918 H1N1 pandemic...

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Main Authors: Srinivasan, Aravind, Viswanathan, Karthik, Raman, Rahul, Chandrasekaran, Aarthi, Raguram, S., Tumpey, Terrence M., Sasisekharan, V., Sasisekharan, Ram
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268540/
https://ncbi.nlm.nih.gov/pubmed/18287068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711963105
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