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NPXY Motifs in the β1 Integrin Cytoplasmic Tail Are Required for Functional Reovirus Entry

Reovirus cell entry is mediated by attachment to cell surface carbohydrate and junctional adhesion molecule A (JAM-A) and internalization by β1 integrin. The β1 integrin cytoplasmic tail contains two NPXY motifs, which function in recruitment of adaptor proteins and clathrin for endocytosis and serv...

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Auteurs principaux: Maginnis, Melissa S., Mainou, Bernardo A., Derdowski, Aaron, Johnson, Elizabeth M., Zent, Roy, Dermody, Terence S.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2008
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268482/
https://ncbi.nlm.nih.gov/pubmed/18216114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01612-07
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