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Proteolytic Cleavage of VP1-2 Is Required for Release of Herpes Simplex Virus 1 DNA into the Nucleus

In this report we propose a model in which after the herpes simplex virus (HSV) capsid docks at the nuclear pore, the tegument protein attached to the capsid must be cleaved by a serine or a cysteine protease in order for the DNA to be released into the nucleus. In support of the model are the follo...

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Hlavní autoři: Jovasevic, Vladimir, Liang, Li, Roizman, Bernard
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268474/
https://ncbi.nlm.nih.gov/pubmed/18216103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01919-07
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