A Single-Amino-Acid Mutation in Hepatitis C Virus NS5A Disrupting FKBP8 Interaction Impairs Viral Replication

Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) regulates viral replication through its interaction with host and other viral proteins. We have previously shown that FK506-binding protein 8 (FKBP8) binds to NS5A and recruits Hsp90 to form a complex that participates in the replication of HCV...

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Autors principals: Okamoto, Toru, Omori, Hiroko, Kaname, Yuuki, Abe, Takayuki, Nishimura, Yorihiro, Suzuki, Tetsuro, Miyamura, Tatsuo, Yoshimori, Tamotsu, Moriishi, Kohji, Matsuura, Yoshiharu
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
Matèries:
Genome Replication and Regulation of Viral Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268450/
https://ncbi.nlm.nih.gov/pubmed/18216108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02253-07
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