Downregulation of Protein 4.1R, a Mature Centriole Protein, Disrupts Centrosomes, Alters Cell Cycle Progression, and Perturbs Mitotic Spindles and Anaphase

Centrosomes nucleate and organize interphase microtubules and are instrumental in mitotic bipolar spindle assembly, ensuring orderly cell cycle progression with accurate chromosome segregation. We report that the multifunctional structural protein 4.1R localizes at centrosomes to distal/subdistal re...

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Detalhes bibliográficos
Main Authors: Krauss, Sharon Wald, Spence, Jeffrey R., Bahmanyar, Shirin, Barth, Angela I. M., Go, Minjoung M., Czerwinski, Debra, Meyer, Adam J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268423/
https://ncbi.nlm.nih.gov/pubmed/18212055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02021-07
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