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WRN Controls Formation of Extrachromosomal Telomeric Circles and Is Required for TRF2(ΔB)-Mediated Telomere Shortening
Telomere dysfunction has been proposed to contribute to the pathogenesis of Werner syndrome (WS), a premature-aging disorder. The WS protein WRN binds TRF2, a telomere-specific factor that protects chromosome ends. TRF2 possesses an amino-terminal domain that plays an essential role in preventing te...
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| Asıl Yazarlar: | , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Microbiology (ASM)
2008
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2268394/ https://ncbi.nlm.nih.gov/pubmed/18212065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01364-07 |
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