Considerable Differences in Vaccine Immunogenicities and Efficacies Related to the Diluent Used for Aluminum Hydroxide Adjuvant

We are developing an anticandidal vaccine using the recombinant N terminus of Als3p (rAls3p-N). We report that although more rAls3p-N was bound by aluminum hydroxide diluted in saline than by aluminum hydroxide diluted in phosphate-buffered saline (PBS), its immunogenicity and efficacy were superior...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lin, Lin, Ibrahim, Ashraf S., Avanesian, Valentina, Edwards, John E., Fu, Yue, Baquir, Beverlie, Taub, Rebecca, Spellberg, Brad
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2008
Pynciau:
Vaccine Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268268/
https://ncbi.nlm.nih.gov/pubmed/18184821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00427-07
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