A Drosophila model for LRRK2-linked parkinsonism

Mutations in the leucine-rich repeat kinase (LRRK2) gene cause late-onset autosomal dominant Parkinson's disease (PD) with pleiomorphic pathology. Previously, we and others found that expression of mutant LRRK2 causes neuronal degeneration in cell culture. Here we used the GAL4/UAS system to ge...

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Main Authors: Liu, Zhaohui, Wang, Xiaoyue, Yu, Yi, Li, Xueping, Wang, Tao, Jiang, Haibing, Ren, Qiuting, Jiao, Yuchen, Sawa, Akira, Moran, Timothy, Ross, Christopher A., Montell, Craig, Smith, Wanli W.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2008
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268198/
https://ncbi.nlm.nih.gov/pubmed/18258746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708452105
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