The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum

The PD-1 costimulatory receptor inhibits T cell receptor signaling upon interacting with its ligands PD-L1 and PD-L2. The PD-1/PD-L pathway is critical in maintaining self-tolerance. In this study, we examined the role of PD-1 in a mouse model of acute infection with Histoplasma capsulatum, a major...

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Библиографические подробности
Главные авторы: Lázár-Molnár, Eszter, Gácser, Attila, Freeman, Gordon J., Almo, Steven C., Nathenson, Stanley G., Nosanchuk, Joshua D.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2008
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268192/
https://ncbi.nlm.nih.gov/pubmed/18268348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711918105
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