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The same mutation in Gsα and transducin α reveals behavioral differences between these highly homologous G protein α-subunits

Mutating Arg-238 to Glu (R238E) in the switch 3 region of a transducin α (*Tα) in which 27 aa of the GTPase domain have been replaced with those of the α-subunit of the inhibitory G protein 1 (Gi1α), was reported to create an α-subunit that is resistant to activation by GTPγS, is devoid of resident...

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Detalhes bibliográficos
Main Authors: Zurita, Adolfo R., Birnbaumer, Lutz
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268142/
https://ncbi.nlm.nih.gov/pubmed/18258741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712261105
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