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Clinical pharmacological issues in the development of acute stroke therapies
The demonstration of the ischaemic penumbra in animal models and the effectiveness of reperfusion therapy in humans led to considerable optimism for neuroprotection in acute stroke. Initial experience with failure of phase II and III trials led to the STAIR recommendations for pre-clinical and clini...
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| Format: | Artigo |
| Language: | Inglês |
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Nature Publishing Group
2008
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2268049/ https://ncbi.nlm.nih.gov/pubmed/18311155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707654 |
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