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Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention?
There is growing interest in the various mechanisms that regulate chromatin remodeling, including modulation of histone deacetylase (HDAC) activities. Competitive HDAC inhibitors disrupt the cell cycle and/or induce apoptosis via de-repression of genes such as P21 and BAX, and cancer cells appear to...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2267878/ https://ncbi.nlm.nih.gov/pubmed/16267097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgi253 |
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