Increased Microerythrocyte Count in Homozygous α(+)-Thalassaemia Contributes to Protection against Severe Malarial Anaemia

BACKGROUND: The heritable haemoglobinopathy α(+)-thalassaemia is caused by the reduced synthesis of α-globin chains that form part of normal adult haemoglobin (Hb). Individuals homozygous for α(+)-thalassaemia have microcytosis and an increased erythrocyte count. α(+)-Thalassaemia homozygosity confe...

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Main Authors: Fowkes, Freya J. I, Allen, Stephen J, Allen, Angela, Alpers, Michael P, Weatherall, David J, Day, Karen P
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267813/
https://ncbi.nlm.nih.gov/pubmed/18351796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0050056
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