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Downregulation of Matrix Metalloproteinase-2 (MMP-2) Utilizing Adenovirus-mediated Transfer of Small Interfering RNA (siRNA) in a Novel Spinal Metastatic Melanoma Model
Matrix metalloproteinases (MMPs) comprise a class of secreted zinc-dependent endopeptidases implicated in the metastatic potential of tumor cells due to their ability to degrade the extracellular matrix (ECM) and basement membrane. Matrix metalloproteinase-2 (MMP-2) has been detected in high levels...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2267753/ https://ncbi.nlm.nih.gov/pubmed/18292932 |
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