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Predicting synthetic rescues in metabolic networks

An important goal of medical research is to develop methods to recover the loss of cellular function due to mutations and other defects. Many approaches based on gene therapy aim to repair the defective gene or to insert genes with compensatory function. Here, we propose an alternative, network-base...

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Autors principals: Motter, Adilson E, Gulbahce, Natali, Almaas, Eivind, Barabási, Albert-László
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267730/
https://ncbi.nlm.nih.gov/pubmed/18277384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2008.1
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