The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket

OSBP (oxysterol-binding protein) homologues, ORPs (OSBP-related proteins), constitute a 12-member family in mammals. We employed an in vitro [(3)H]25OH (25-hydroxycholesterol)-binding assay with purified recombinant proteins as well as live cell photo-cross-linking with [(3)H]photo-25OH and [(3)H]ph...

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Detalhes bibliográficos
Main Authors: Suchanek, Monika, Hynynen, Riikka, Wohlfahrt, Gerd, Lehto, Markku, Johansson, Marie, Saarinen, Hannu, Radzikowska, Anna, Thiele, Christoph, Olkkonen, Vesa M.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267293/
https://ncbi.nlm.nih.gov/pubmed/17428193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070176
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