Improvement of vascular function by acute and chronic treatment with the PDE-5 inhibitor sildenafil in experimental diabetes mellitus

BACKGROUND AND PURPOSE: Diabetes-associated vascular dysfunction contributes to increased cardiovascular risk. We investigated whether the phosphodiesterase-5 inhibitor sildenafil would improve vascular function in diabetic rats. EXPERIMENTAL APPROACH: Male Wistar rats were injected with streptozoto...

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Detalhes bibliográficos
Main Authors: Schäfer, A, Fraccarollo, D, Pförtsch, S, Flierl, U, Vogt, C, Pfrang, J, Kobsar, A, Renné, T, Eigenthaler, M, Ertl, G, Bauersachs, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267262/
https://ncbi.nlm.nih.gov/pubmed/17891166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707459
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