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A model of aging as accumulated damage matches observed mortality patterns and predicts the life-extending effects of prospective interventions
The relative insensitivity of lifespan to environmental factors constitutes compelling evidence that the physiological decline associated with aging derives primarily from the accumulation of intrinsic molecular and cellular side-effects of metabolism. Here we model that accumulation starting from a...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Springer Netherlands
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2267031/ https://ncbi.nlm.nih.gov/pubmed/19424837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-007-9038-8 |
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