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Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism

Becoming a phenotypic male is ultimately determined by androgen-induced masculinization. Disorders of fetal masculinization, resulting in hypospadias or cryptorchidism, are common, but their cause remains unclear. Together with the adult-onset disorders low sperm count and testicular cancer, they ca...

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Auteurs principaux: Welsh, Michelle, Saunders, Philippa T.K., Fisken, Mark, Scott, Hayley M., Hutchison, Gary R., Smith, Lee B., Sharpe, Richard M.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2008
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267017/
https://ncbi.nlm.nih.gov/pubmed/18340380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34241
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