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Obesity and HER 2 overexpression: a common factor for poor prognosis of breast cancer

BACKGROUND: Both obesity and over-expression of HER II are associated with poor prognosis of breast cancer. In vitro experiments suggest that anti-tumour activity of the anti-obesity drug Orlistat is likely to be due to transcriptional suppression of HER II expression. The overexpression of HER II i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Sellahewa, Chaminda, Nightingale, Peter, Carmichael, Amtul R
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2266765/
https://ncbi.nlm.nih.gov/pubmed/18294401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-7800-5-2
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