Diacylglycerol kinase ζ inhibits myocardial atrophy and restores cardiac dysfunction in streptozotocin-induced diabetes mellitus

BACKGROUND: Activation of the diacylglycerol (DAG)-protein kinase C (PKC) pathway has been implicated in the pathogenesis of a number of diabetic complications. Diacylglycerol kinase (DGK) converts DAG to phosphatidic acid and acts as an endogenous regulator of PKC activity. Akt/PKB is associated wi...

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Detalhes bibliográficos
Main Authors: Bilim, Olga, Takeishi, Yasuchika, Kitahara, Tatsuro, Arimoto, Takanori, Niizeki, Takeshi, Sasaki, Toshiki, Goto, Kaoru, Kubota, Isao
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265681/
https://ncbi.nlm.nih.gov/pubmed/18241357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-7-2
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