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Mutations of Different Molecular Origins Exhibit Contrasting Patterns of Regional Substitution Rate Variation

Transitions at CpG dinucleotides, referred to as “CpG substitutions”, are a major mutational input into vertebrate genomes and a leading cause of human genetic disease. The prevalence of CpG substitutions is due to their mutational origin, which is dependent on DNA methylation. In comparison, other...

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Библиографические подробности
Главные авторы: Elango, Navin, Kim, Seong-Ho, Vigoda, Eric, Yi, Soojin V.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265638/
https://ncbi.nlm.nih.gov/pubmed/18463707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000015
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