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FOXO-regulated transcription restricts overgrowth of Tsc mutant organs

FOXO is thought to function as a repressor of growth that is, in turn, inhibited by insulin signaling. However, inactivating mutations in Drosophila melanogaster FOXO result in viable flies of normal size, which raises a question over the involvement of FOXO in growth regulation. Previously, a growt...

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Main Authors: Harvey, Kieran F., Mattila, Jaakko, Sofer, Avi, Bennett, F. Christian, Ramsey, Matthew R., Ellisen, Leif W., Puig, Oscar, Hariharan, Iswar K.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265581/
https://ncbi.nlm.nih.gov/pubmed/18299344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200710100
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