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Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: Mechanisms for aquaporin 2 down-regulation and cellular proliferation

Lithium is a commonly prescribed mood-stabilizing drug. However, chronic treatment with lithium induces numerous kidney-related side effects, such as dramatically reduced aquaporin 2 (AQP2) abundance, altered renal function, and structural changes. As a model system, inner medullary collecting ducts...

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Detalhes bibliográficos
Main Authors: Nielsen, Jakob, Hoffert, Jason D., Knepper, Mark A., Agre, Peter, Nielsen, Søren, Fenton, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265122/
https://ncbi.nlm.nih.gov/pubmed/18296634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800001105
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