Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control

In fission yeast, the rad3 gene product plays a critical role in sensing DNA structure defects and activating damage response pathways. A structural homologue of rad3 in humans (ATR) has been identified based on sequence similarity in the protein kinase domain. General information regarding ATR expr...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Wright, Jocyndra A., Keegan, Kathleen S., Herendeen, Daniel R., Bentley, Nicola J., Carr, Antony M., Hoekstra, Merl F., Concannon, Patrick
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The National Academy of Sciences 1998
विषय:
Biological Sciences
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC22645/
https://ncbi.nlm.nih.gov/pubmed/9636169
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