Isc1p Plays a Key Role in Hydrogen Peroxide Resistance and Chronological Lifespan through Modulation of Iron Levels and Apoptosis

The inositolphosphosphingolipid phospholipase C (Isc1p) of Saccharomyces cerevisiae belongs to the family of neutral sphingomyelinases that generates the bioactive sphingolipid ceramide. In this work the role of Isc1p in oxidative stress resistance and chronological lifespan was investigated. Loss o...

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Main Authors: Almeida, Teresa, Marques, Marta, Mojzita, Dominik, Amorim, Maria A., Silva, Rui D., Almeida, Bruno, Rodrigues, Pedro, Ludovico, Paula, Hohmann, Stefan, Moradas-Ferreira, Pedro, Côrte-Real, Manuela, Costa, Vítor
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2262964/
https://ncbi.nlm.nih.gov/pubmed/18162582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-06-0604
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