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Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering

A previously unknown chemical structure, 6-desmethyl-6-ethylerythromycin A (6-ethylErA), was produced through directed genetic manipulation of the erythromycin (Er)-producing organism Saccharopolyspora erythraea. In an attempt to replace the methyl side chain at the C-6 position of the Er polyketide...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Stassi, D. L., Kakavas, S. J., Reynolds, K. A., Gunawardana, G., Swanson, S., Zeidner, D., Jackson, M., Liu, H., Buko, A., Katz, L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 1998
Schlagworte:
Biological Sciences
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22598/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9636144/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.13.7305
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