Role of the NO/cGMP/K(ATP) pathway in the protective effects of sildenafil against ethanol-induced gastric damage in rats

BACKGROUND AND PURPOSE: Sildenafil is a selective inhibitor of cGMP-specific phosphodiesterase. Sildenafil, acting via NO-dependent mechanisms, prevents indomethacin-induced gastropathy. Activation of ATP-sensitive potassium channels (K(ATP)) is involved in gastric defence. Our objective was to eval...

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Detalhes bibliográficos
Principais autores: Medeiros, J V R, Gadelha, G G, Lima, S J, Garcia, J A, Soares, P M G, Santos, A A, Brito, G A C, Ribeiro, R A, Souza, M H L P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2259210/
https://ncbi.nlm.nih.gov/pubmed/18071300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707605
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