Selective Downregulation of Rhesus Macaque and Sooty Mangabey Major Histocompatibility Complex Class I Molecules by Nef Alleles of Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2

Human immunodeficiency virus type 1 (HIV-1) Nef downregulates HLA-A and -B molecules, but not HLA-C or -E molecules, based on amino acid differences in their cytoplasmic domains to simultaneously evade cytotoxic T lymphocyte (CTL) and natural killer cell surveillance. Rhesus macaques and sooty manga...

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Autores principales: DeGottardi, M. Quinn, Specht, Anke, Metcalf, Benjamin, Kaur, Amitinder, Kirchhoff, Frank, Evans, David T.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2008
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258998/
https://ncbi.nlm.nih.gov/pubmed/18199657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02102-07
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