Hepatitis C Virus Core Protein Upregulates Serine Phosphorylation of Insulin Receptor Substrate-1 and Impairs the Downstream Akt/Protein Kinase B Signaling Pathway for Insulin Resistance

Chronic hepatitis C virus (HCV) infection has a significantly increased prevalence of type 2 diabetes mellitus (T2DM). Insulin resistance is a critical component of T2DM pathogenesis. Several mechanisms are likely to be involved in the pathogenesis of HCV-related insulin resistance. Since we and oth...

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Bibliographic Details
Main Authors: Banerjee, Sutapa, Saito, Kousuke, Ait-Goughoulte, Malika, Meyer, Keith, Ray, Ratna B., Ray, Ranjit
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Cellular Response to Infection
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258989/
https://ncbi.nlm.nih.gov/pubmed/18160431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01672-07
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