Subacute Toxicity of Colistin Methanesulfonate in Rats: Comparison of Various Intravenous Dosage Regimens

The relative nephro- and neurotoxicity of colistin methanesulfonate (CMS) was investigated with rats during 7 days of intravenous administration in regimens mimicking twice- and once-daily dosing of a clinically relevant dose for humans. Histological examination revealed more-severe renal lesions wi...

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Main Authors: Wallace, Stephanie J., Li, Jian, Nation, Roger L., Rayner, Craig R., Taylor, David, Middleton, Deborah, Milne, Robert W., Coulthard, Kingsley, Turnidge, John D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2008
Teme:
Experimental Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258545/
https://ncbi.nlm.nih.gov/pubmed/18180359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01101-07
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