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Dectin-1 Fc Targeting of Aspergillus fumigatus Beta-Glucans Augments Innate Defense against Invasive Pulmonary Aspergillosis

Invasive pulmonary aspergillosis (IPA) has significantly increased over the last decade. Here, a fusion protein consisting of the Dectin-1 extracellular domain linked to the Fc portion of murine immunoglobulin G1 augmented alveolar macrophage killing of Aspergillus fumigatus and shifted mortality as...

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Autori principali: Mattila, Polly E., Metz, Allison E., Rapaka, Rekha R., Bauer, Lynne D., Steele, Chad
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258489/
https://ncbi.nlm.nih.gov/pubmed/18086835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01274-07
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