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Impaired Luminal Processing of Human Defensin-5 in Crohn’s Disease : Persistence in a Complex with Chymotrypsinogen and Trypsin
Human defensin (HD)-5 is an antimicrobial peptide expressed in small intestinal Paneth cells, and alterations in HD-5 expression may be important in Crohn’s disease (CD) pathogenesis. Levels of HD-5 in Paneth cells and ileostomy fluid from control and CD patients were studied by quantitative immunod...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Investigative Pathology
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2258249/ https://ncbi.nlm.nih.gov/pubmed/18258845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070755 |
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