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MECHANISMS OF RETINAL GANGLION SPECIFIC-CELL DEATH IN LEBER HEREDITARY OPTIC NEUROPATHY
PURPOSE: Leber hereditary optic neuropathy (LHON) results from point mutations in mitochondrial DNA (mtDNA) present in all cells but is only manifested in retinal ganglion cells (RGCs). Given that RGCs use superoxide for intracellular signaling after axotomy, and that LHON mutations increase superox...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Ophthalmological Society
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2258117/ https://ncbi.nlm.nih.gov/pubmed/18427623 |
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