Rho-kinase-dependent F-actin rearrangement is involved in the inhibition of PI3-kinase/Akt during ischemia–reperfusion-induced endothelial cell apoptosis

Activation of cytoskeleton regulator Rho-kinase during ischemia–reperfusion (I/R) plays a major role in I/R injury and apoptosis. Since Rho-kinase is a negative regulator of the pro-survival phosphatidylinositol 3-kinase (PI3-kinase)/Akt pathway, we hypothesized that inhibition of Rho-kinase can pre...

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Autori principali: van der Heijden, Melanie, Versteilen, Amanda M. G., Sipkema, Pieter, van Nieuw Amerongen, Geerten P., Musters, Rene J. P., Groeneveld, A. B. Johan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2007
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2257993/
https://ncbi.nlm.nih.gov/pubmed/18165899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-007-0173-6
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