Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma

BACKGROUND: Cyclooxygenase-2 (COX-2, PTGS2) plays an important role in colorectal carcinogenesis. COX-2 overexpression in colorectal cancer is inversely associated with microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP). Evidence suggests that MSI/CIMP+ colorectal cancer...

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Autori principali: Kawasaki, Takako, Nosho, Katsuhiko, Ohnishi, Mutsuko, Suemoto, Yuko, Glickman, Jonathan N, Chan, Andrew T, Kirkner, Gregory J, Mino-Kenudson, Mari, Fuchs, Charles S, Ogino, Shuji
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2257954/
https://ncbi.nlm.nih.gov/pubmed/18230181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-33
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