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Shifting Paradigm of Association Studies: Value of Rare Single-Nucleotide Polymorphisms
Currently, single-nucleotide polymorphisms (SNPs) with minor allele frequency (MAF) of >5% are preferentially used in case-control association studies of common human diseases. Recent technological developments enable inexpensive and accurate genotyping of a large number of SNPs in thousands of c...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Human Genetics
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2253956/ https://ncbi.nlm.nih.gov/pubmed/18179889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2007.09.006 |
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