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Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor α soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects

Adenoviral vectors were used to deliver genes encoding a soluble interleukin 1 (IL-1)-type I receptor-IgG fusion protein and/or a soluble type I tumor necrosis factor α (TNFα) receptor-IgG fusion protein directly to the knees of rabbits with antigen-induced arthritis. When tested individually, knees...

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Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Ghivizzani, Steven C., Lechman, Eric R., Kang, Richard, Tio, Caroline, Kolls, Jay, Evans, Christopher H., Robbins, Paul D.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1998
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22538/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9539786/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.8.4613
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