Inhibition of IGF-1R and Lipoxygenase by Nordihydroguaiaretic Acid (NDGA) Analogs

Herein we pursue the hypothesis that the structure of nordihydroguaiaretic acid (NDGA) can be refined for selective potency against the insulin-like growth factor 1 receptor (IGF-1R) as a potential therapeutic target for breast cancer while diminishing its action against other cellular targets. Thus...

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Detalhes bibliográficos
Main Authors: Blecha, Joseph E., Anderson, Marc O., Chow, Jennifer M., Guevarra, Christle C., Pender, Celia, Penaranda, Cristina, Zavodovskaya, Marianna, Youngren, Jack F., Berkman, Clifford E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2253493/
https://ncbi.nlm.nih.gov/pubmed/17502145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.04.092
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