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Kinetic and crystallographic studies on 2-(β-D-glucopyranosyl)-5-methyl-1, 3, 4-oxadiazole, -benzothiazole, and -benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site

In an attempt to identify leads that would enable the design of inhibitors with enhanced affinity for glycogen phosphorylase (GP), that might control hyperglycaemia in type 2 diabetes, three new analogs of β-D-glucopyranose, 2-(β-D-glucopyranosyl)-5-methyl-1, 3, 4-oxadiazole, -benzothiazole, and -be...

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Main Authors: Chrysina, Evangelia D., Kosmopoulou, Magda N., Tiraidis, Constantinos, Kardakaris, Rozina, Bischler, Nicolas, Leonidas, Demetres D., Hadady, Zsuzsa, Somsak, Laszlo, Docsa, Tibor, Gergely, Pal, Oikonomakos, Nikos G.
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2005
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2253430/
https://ncbi.nlm.nih.gov/pubmed/15741340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.041216105
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