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Modifications of human βA1/βA3-crystallins include S-methylation, glutathiolation, and truncation

Disulfide bonding of lens crystallins contributes to the aggregation and insolubilization of these proteins that leads to cataract. A high concentration of reduced glutathione is believed to be key in preventing oxidation of crystallin sulfhydryls to form disulfide bonds. This protective role is dec...

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Bibliografski detalji
Glavni autori: Lapko, Veniamin N., Cerny, Ronald L., Smith, David L., Smith, Jean B.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2005
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2253330/
https://ncbi.nlm.nih.gov/pubmed/15576560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.04738505
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