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Thermodynamic consequences of disrupting a water-mediated hydrogen bond network in a protein:pheromone complex
The mouse pheromones (±)-2-sec-butyl-4,5-dihydrothiazole (SBT) and 6-hydroxy-6-methyl-3-heptanone (HMH) bind into an occluded hydrophobic cavity in the mouse major urinary protein (MUP-1). Although the ligands are structurally unrelated, in both cases binding is accompanied by formation of a similar...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2005
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2253314/ https://ncbi.nlm.nih.gov/pubmed/15608125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.04912605 |
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