Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade

It is not known how human immunodeficiency virus type 1 (HIV-1)-derived antagonist peptides interfere with intracellular activation of cytotoxic T lymphocytes (CTL). We identified Gag epitope variants in HIV-1-infected patients that act as antagonists of CTL responses to unmutated epitopes. We then...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Purbhoo, Marco A., Sewell, Andrew K., Klenerman, Paul, Goulder, Philip J. R., Hilyard, Katherine L., Bell, John I., Jakobsen, Bent K., Phillips, Rodney E.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22523/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9539771/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.8.4527
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