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Mimicking the action of GroEL in molecular dynamics simulations: Application to the refinement of protein structures

Bacterial chaperonin, GroEL, together with its co-chaperonin, GroES, facilitates the folding of a variety of polypeptides. Experiments suggest that GroEL stimulates protein folding by multiple cycles of binding and release. Misfolded proteins first bind to an exposed hydrophobic surface on GroEL. Gr...

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Detalhes bibliográficos
Main Authors: Fan, Hao, Mark, Alan E.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2249765/
https://ncbi.nlm.nih.gov/pubmed/16452612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051721006
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