Recombinant Virus Vaccination against “Self” Antigens Using Anchor-fixed Immunogens

To study the induction of anti-“self” CD8(+) T-cell reactivity against the tumor antigen gp100, we used a mouse transgenic for a chimeric HLA-A*0201/H-2 K(b) molecule (A2/K(b)). We immunized the mice with a recombinant vaccinia virus encoding a form of gp100 that had been modified at position 210 (f...

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Main Authors: Irvine, Kari R., Parkhurst, Maria R., Shulman, Eliza P., Tupesis, Janis P., Custer, Mary, Touloukian, Christopher E., Robbins, Paul F., Yafal, Alicia Gómez, Greenhalgh, Patricia, Sutmuller, Roger P. M., Offringa, Rienk, Rosenberg, Steven A., Restifo, Nicholas P.
Format: Artigo
Language:Inglês
Published: 1999
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2249691/
https://ncbi.nlm.nih.gov/pubmed/10363968
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