Purification, Characterization, and Immunogenicity of a Soluble Trimeric Envelope Protein Containing a Partial Deletion of the V2 Loop Derived from SF162, an R5-Tropic Human Immunodeficiency Virus Type 1 Isolate

The envelope (Env) glycoprotein of human immunodeficiency virus type 1 (HIV-1) is the major target of neutralizing antibody responses and is likely to be a critical component of an effective vaccine against AIDS. Although monomeric HIV envelope subunit vaccines (gp120) have induced high-titer antibo...

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Détails bibliographiques
Auteurs principaux: Srivastava, Indresh K., Stamatatos, Leonidas, Kan, Elaine, Vajdy, Michael, Lian, Ying, Hilt, Susan, Martin, Loic, Vita, Claudio, Zhu, Ping, Roux, Kenneth H., Vojtech, Lucia, C. Montefiori, David, Donnelly, John, Ulmer, Jeffrey B., Barnett, Susan W.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2003
Sujets:
Vaccines and Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC224963/
https://ncbi.nlm.nih.gov/pubmed/14512572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.20.11244-11259.2003
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