Purification, Characterization, and Immunogenicity of a Soluble Trimeric Envelope Protein Containing a Partial Deletion of the V2 Loop Derived from SF162, an R5-Tropic Human Immunodeficiency Virus Type 1 Isolate

The envelope (Env) glycoprotein of human immunodeficiency virus type 1 (HIV-1) is the major target of neutralizing antibody responses and is likely to be a critical component of an effective vaccine against AIDS. Although monomeric HIV envelope subunit vaccines (gp120) have induced high-titer antibo...

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Main Authors: Srivastava, Indresh K., Stamatatos, Leonidas, Kan, Elaine, Vajdy, Michael, Lian, Ying, Hilt, Susan, Martin, Loic, Vita, Claudio, Zhu, Ping, Roux, Kenneth H., Vojtech, Lucia, C. Montefiori, David, Donnelly, John, Ulmer, Jeffrey B., Barnett, Susan W.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2003
Teme:
Vaccines and Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC224963/
https://ncbi.nlm.nih.gov/pubmed/14512572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.20.11244-11259.2003
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