SnoRNA Snord116 (Pwcr1/MBII-85) Deletion Causes Growth Deficiency and Hyperphagia in Mice

Prader-Willi syndrome (PWS) is the leading genetic cause of obesity. After initial severe hypotonia, PWS children become hyperphagic and morbidly obese, if intake is not restricted. Short stature with abnormal growth hormone secretion, hypogonadism, cognitive impairment, anxiety and behavior problem...

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Detalhes bibliográficos
Main Authors: Ding, Feng, Li, Hong Hua, Zhang, Shengwen, Solomon, Nicola M., Camper, Sally A., Cohen, Pinchas, Francke, Uta
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248623/
https://ncbi.nlm.nih.gov/pubmed/18320030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001709
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